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    HomeBusinessTakeda’s Dengue vaccine candidate provides extended protection through 4.5 Years in clinical...

    Takeda’s Dengue vaccine candidate provides extended protection through 4.5 Years in clinical trial

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    Moreover, TAK-003 is currently undergoing regulatory review for the prevention of dengue disease in children and adults in the European Union and select dengue-endemic countries.

    Takeda on Friday announced that its dengue vaccine candidate, TAK-003, prevented 84 percent of hospitalized dengue cases and 61 percent of symptomatic cases, with no important safety risks identified, in the overall population including both seropositive and seronegative individuals through four and a half years (54 months) after vaccination in the pivotal Phase 3 Tetravalent Immunization against Dengue Efficacy Study (TIDES) trial. The company in its press statement informed that the data were presented on Thursday at the 8th Northern European Conference on Travel Medicine (NECTM8), with plans to feature the results at additional upcoming conferences.

    “The burden of dengue is far-reaching, and over half of the world’s population is at risk of dengue each year. There is an urgent need for impactful prevention tools to combat the disease. The long-term TIDES results indicate that TAK-003 could be an important addition to the limited tools we have to prevent dengue, particularly given the demonstrated protection against hospitalizations,” said Eng Eong Ooi, PhD, MD, Duke-NUS Medical School, Singapore in a statement.

    According to the World Health Organisation, 70 percent of the disease burden of dengue rests in Asia and India accounts for 33 million clinically apparent dengue cases every year contributing to a third of the total global dengue burden.

    “There is a dengue outbreak almost every year in India. The dengue burden underscores the need for new vaccines. The data from the TIDES trial provide hope for a long-term solution in the fight against dengue, said Serina Fischer, General Manager – India, Takeda.”

    “Through four and a half years, TAK-003 demonstrated 84.1 percent vaccine efficacy (VE) (95% CI: 77.8, 88.6) against hospitalized dengue, with 85.9% VE (78.7, 90.7) in seropositive individuals and 79.3 percent VE (63.5, 88.2) in seronegative individuals. TAK-003 also demonstrated overall VE of 61.2% (95% CI: 56.0, 65.8) against virologically-confirmed dengue (VCD), with 64.2% VE (58.4, 69.2) in seropositive individuals and 53.5% VE (41.6, 62.9) in seronegative individuals. Observations of VE varied by serotype and remained consistent with previously reported results. TAK-003 was generally well tolerated, and there were no important safety risks identified. No evidence of disease enhancement was observed over the 54-month follow-up exploratory analysis,” the company said in a statement.

    “Dengue is a complex, global disease, and the TIDES trial was designed to account for this, including both dengue-naïve and dengue-exposed populations in Latin America and Asia where outbreaks are prevalent, with evaluation over four and a half years. We are proud that the results continue to demonstrate the efficacy and safety of TAK-003 and its ability to provide long-term protection against dengue,” said Gary Dubin, President, Global Vaccine Business Unit at Takeda.

    The company in its press statement announced that these new long-term results supplement previously published TIDES data that demonstrated the candidate vaccine met its primary endpoint of overall VE against VCD, with 80.2 percent efficacy at 12-months follow-up, as well as all secondary endpoints for which there were a sufficient number of dengue cases at 18-months follow-up, including 90.4% VE against hospitalized dengue.

    “While the long-term follow-up for the primary two-dose series has been completed, the TIDES trial remains ongoing to evaluate the safety and efficacy of a booster dose. The TIDES trial is Takeda’s largest interventional clinical trial to date, enrolling more than 20,000 healthy children and adolescents four to 16 years of age, across eight dengue-endemic countries, over the past four and a half years,” the company stated.

    Moreover, TAK-003 is currently undergoing regulatory review for the prevention of dengue disease in children and adults in the European Union and select dengue-endemic countries.

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