Coronavirus

Evidence used to update the list of underlying medical conditions that increase a person’s risk of severe illness from COVID-19

Strongest and Most Consistent Evidence Cancer Systematic Review [6] Cohort Study [7,8] Case Series [9] Chronic kidney disease Case Series [10, 11, 12] Cohort Studies [13, 14, 15] COPD Meta Analyses [4, 16] Case Series [17] Cohort Study [14] Heart conditions, such as heart failure, coronary artery disease, or cardiomyopathies Cohort Study [1, 2] Meta…

Strongest and Most Consistent Evidence Cancer Systematic Review [6] Cohort Study [7,8] Case Series [9] Chronic kidney disease Case Series [10, 11, 12] Cohort Studies [13, 14, 15] COPD Meta Analyses [4, 16] Case Series [17] Cohort Study [14] Heart conditions, such as heart failure, coronary artery disease, or cardiomyopathies Cohort Study [1, 2] Meta Analyses [3, 4] Case Series [5] Obesity (BMI> 30 kg/m2) Cohort Studies [18, 19, 20, 21, 22] Cross-sectional [23] Severe Obesity (BMI ≥ 40 kg/m2) Cohort Study [98, 99] Cross-Sectional Study [95] Meta Analysis [107] Pregnancy Systematic Review [54, 116] Case Control Study [55] Case Series [56, 57, 58, 59] Cohort Study [60, 61, 62, 117] Sickle cell disease Case Series [24, 25, 26, 27, 28] Smoking Meta Analyses [3, 16*, 63, 64, 65, 66, 101, 102, 104, 105] Solid organ transplantation Case Series [12, 29, 30, 31, 32, 33, 34] Meta Analysis [100] Type 2 diabetes mellitus Case Series [11] Longitudinal Study [35] Cohort Study [36, 37] Meta Analysis [38] Cross-Sectional Study [114] Mixed Evidence Asthma Cohort Study [14, 39, 40, 41] Case Series [17] Cerebrovascular disease Meta Analysis [42, 43, 44, 45] Synthesis of Evidence [46] Cohort Study [1, 2, 47, 48, 49] Hypertension Cohort Study [1, 2, 49, 50, 51, 91, 93] Case Series [92] Systematic Review [52] Meta Analyses [3, 4, 53, 94] Use of corticosteroids or other immunosuppressive medications Case Series [67, 68, 69] Cohort Study [70, 71] Limited Evidence Bone marrow transplantation Review [72] HIV Case Series [73, 74] Cohort Study [109, 110, 111, 112] Immune deficiencies Case Series [75] Systematic Review [76] Inherited metabolic disorders Cohort Study [47, 77] Liver disease Meta-Analysis [78] Cohort  Study [79, 80, 118, 119] Literature Review [81] Case Control Study [120] Neurologic conditions Cross-Sectional Study [82] Cohort Study [41, 49, 77] Other chronic lung diseases Meta-Analysis [4] Case Series [17] Cohort Study [14, 83] Overweight (BMI > 25 kg/m2, but < 30 kg/m2) Cohort Study [96, 106] Case Series [97] Meta Analysis [115] Pediatrics Systematic Review [84, 85] Cross-Sectional Study [82, 86, 107] Cohort Study [77, 87, 88, 103, 108, 113,121, 122, 125] Case Series [123, 124] Thalassemia Case Series [89] Cross-Sectional Study [90] Type 1 diabetes mellitus Case Series [11] Cohort Study [36, 37] Meta-Analysis [38] Cross-Sectional Study [114]

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