Northern Ireland Secretary Julian Smith and Enterprise Secretary Andrea Leadsom are amongst the early casualties as Boris Johnson begins a cabinet reshuffle.
Housing Minister Esther McVey and Environment Secretary Theresa Villiers are additionally out of the executive.
Attorney Identical previous Geoffrey Cox, who attended cupboard, has resigned.
Senior figures such as Chancellor Sajid Javid, Foreign Secretary Dominic Raab and Home Secretary Priti Patel are expected to remain in save.
Most of the cupboard had been appointed when Mr Johnson grew to turn out to be prime minister in July.
In an announcement confirming his resignation as the executive’s most senior regulations officer, Mr Cox talked about: “I in point of fact own been in point of fact privileged to own served as criminal expert overall at some level of the sizzling turbulent political times.”
Known for his booming starting up and his edifying advice that successfully scuppered Theresa May perchance perchance’s Brexit deal in March closing yr, he talked about he had been asked to resign by the prime minister.
Mr Smith has been extensively praised for his instant tenure at the Northern Ireland Office – he used to be in the position lawful 204 days.
His departure comes weeks after brokering the deal which restored the vitality-sharing administration in Stormont.
Mr Smith talked about on Twitter that it had been “the finest privilege” to serve the of us of Northern Ireland and he used to be “extraordinarily grateful” to own been given the prospect to serve “this amazing phase of our country”.
The prime minister left his cupboard largely untouched following the Conservative Event’s decisive election victory in December, pending what sources urged at the time might perchance be a more important overhaul after the UK left the EU on 31 January.
Mr Johnson is anticipated to invent adjustments at junior ministerial diploma – namely parliamentary under-secretaries of negate – that might perchance stumble on a 50/50 gender steadiness in a push to promote female skills.
Education minister Chris Skidmore and transport ministers Nus Ghani and George Freeman own been sacked.
There are expected to be promotions for a chain of female MPs in executive, including Anne-Marie Trevelyan, Suella Braverman and Gillian Keegan.
Cupboard Office minister Oliver Dowden and Global Trend Secretary Alok Sharma are additionally expected to get more outstanding roles.
When she used to be re-appointed as Custom Secretary in December, Baroness Morgan talked about she simplest expected to remain in the position for a couple of months, having stood down as an MP at the election and been appointed a scrutinize.
Among more junior ministers, these tipped for promotion comprise Victoria Atkins, Oliver Dowden, Kwasi Kwarteng and Lucy Frazer, whereas Stephen Barclay might perchance invent a instant return to cupboard after his position as Brexit Secretary used to be scrapped following the UK’s departure from the EU.
Mr Johnson is anticipated to appoint a brand original minister to oversee the constructing of the HS2 rail line, closing approval for which used to be given this week.
He additionally desires to search out someone to lumber the COP26 climate summit in Glasgow later this yr after its previous president Claire Perry O’Neill used to be sacked, and two dilapidated Tory leaders, David Cameron and Lord Hague, rejected the job.
In an announcement on her Fb online page, Ms Villiers talked about: “What the prime minister giveth, the prime minister taketh away: lawful over six months previously, I used to be tickled to be invited by the prime minister to reach to executive after three years on the reduction benches.
“This morning he informed me that I must invent blueprint for somebody original.”
She talked about she used to be “sad” no longer to be a phase of the cupboard, nonetheless she talked about the prime minister would continue to own her “corpulent make stronger”.